Quantitative assessment of the autonomic nervous system. It includes an ECG and HRV Analysis software for display, measurement and interpretation of test results.
Nerve-Express is a fully automatic, non-invasive computer-based system designed for quantitative assessment of the Autonomic Nervous System (ANS) based on Heart Rate Variability (HRV) analysis. Nerve-Express is the first and only system to solve the problem of SNS-PSNS quantification based on method of clusterization of the relationship between SNS and PSNS status.
This technological breakthrough is achieved by using proprietary algorithms and a new approach based on one of the leading theories of Artificial Intelligence - Marvin Minsky's Frame Theory. Nerve-Express objectively and reliably evaluates the state of ANS in "real-time" (up to 24 hours) as well as during Orthostatic test and Valsalva maneuver combined with Deep Breathing. Due to its highly sophisticated HRV analysis, Nerve-Express is the only system that enables quantification of 81 ANS states with a corresponding qualitative description for each one.
Valsalva Maneuver combined with Deep breathing
The algorithms used by Nerve-Express have been developed and tested for over twenty five years in studies involving more than twenty thousand patients . Nerve-Express implements a battery of three tests as the most comprehensive and informative combination of tests for ANS purposes:
1. Orthostatic test as the initial method for ANS provocation;
2. Valsalva maneuver combined with Deep Breathing as the optimal method for revealing the hidden abilities of the Autonomic function and distinguishing between chronic and temporary abnormalities;
3. Real-time Nerve-Monitor test as the ultimate method for ANS assessment in long-term therapy, continuous monitoring (especially, under anesthesia/intensive care), research and experimentation. Real-Time assessment may be conducted on a single patient as well as on two patients simultaneously for psychological purposes for instance: as a lay detector or psychological adaptation between crew members.
Nerve-Express 6.7 system
LIMITED WARRANTY STATEMENTNerve-Express, Inc. provides a limited warranty for the product for the period of three (3) months from the date of shipment from the company to the original customer.The Limited Warranty covers defects in materials and manufacturing of the Nerve-Express, Inc. Software, receiver, and signal cable under normal use and service. A dated proof of purchase is required at the time of the warranty service.
No Returns - Exchange only
Excluded from this warranty are:
- You have three (3) months to exchange an item from the date you received it.
- To be eligible for an exchange, your item must be in the same condition that you received it.
- Your item must be in the original packaging.
- Your item needs to have the receipt or proof of purchase.
- Non-Nerve-Express-brand products, accessories, and details
- Any product that Intellewave, Inc. determines has been damaged or modified by the customer
- Products for which payment has not been received.
Once we receive your item, we will inspect it and notify you that we have received your item to be exchanged. We will immediately notify you of the status of a received item after inspecting the item.
- If your return is approved, we will initiate an exchange to a new item.
- You will be responsible for paying for your own shipping costs for exchanging your item. Shipping costs are nonrefundable.
Technical Support- FREE for first three months, from the purchase date.EXCEPT FOR THE WARRANTIES EXPRESSLY SET FORTH IN THIS LIMITED STATEMENT, NERVE-EXPRESS, INC. DISCLAIMS ALL OTHER WARRANTIES OR CONDITIONS, EXPRESS OR IMPLIED, INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. (THE EXCLUSION OF IMPLIED WARRANTIES IS NOT PERMITTED BY SOME STATES, SO THE ABOVE LIMITATION MAY NOT APPLY TO YOU.) THIS LIMITED WARRANTY SHOULD NOT EXTEND TO ANYONE OTHER THAN THE ORIGINAL PURCHASER OF THE PRODUCT.
The product was originally conceived by its developer Dr. Alexander Riftine for the needs of the Navy. Specifically, the product was to meet the need for objective testing of the general health and special fitness conditions of the Navy pilots, underwater divers, navy seals and other marine personnel.
Between 1981 and 1982 the first trial version of the product was developed based on the Time Domain and Auto-regression Function approach. By 1982 it became clear that the Time Domain approach was fundamentally flawed as it didn't reflect the internal structure of the heart rhythm. It was also revealed that the probability of erroneous assessments was no less than 30%, which was unacceptable.
In 1982 a new trial version was developed based on the Frequency Domain approach.
In 1982 a massive data collection effort was started, and by the summer of 1986 12000 samples of Orthostatic test data and 700 samples of Stress test data were collected and analyzed. One of the results of this analysis was a proprietary Classification of the Transitional Periods during Orthostatic test, developed in 1986.
To provide a meaningful and systematic interpretation for his entire collection of data, Dr. Riftine started searching for a fundamentally new methodology that would be more comprehensive and precise in measuring the individual's current physical/physiological state as well as health resource and genetic ability.
In the first part of 1987, Dr. Riftine formulated a novel theory for the quantitative assessment of the individual's functional state utilizing HRV methodology. This theory was based on Dr. Riftine's original ideas in the field of Bio-medical Cybernetics and Normal Physiology. The practical applications of the theory - specifically, its proprietary algorithms for the quantitative assessment of the individual's functional state - were developed on the basis of Marvin Minsky's Frame Theory.
The first product based on Dr. Riftine's new theory, Health-Express, was developed by 1988. It provided assessment of the level of Physical Fitness. The marketing campaign for Health-Express was launched in 1988.
In 1992 a new product, Nerve-Express, was launched. Nerve-Express is the first product to provide an automatic quantitative assessment of the Autonomic Nervous System(ANS).
Nerve-Express solved a challenging problem of subdividing the Spectral Function of R-R intervals variability into two parts:
- High Frequency (which correlates with Parasympathetic activity 95% of the time) and
- Low Frequency (correlates with Sympathetic activity up to 70% of time).
In the past, the division line (between PNS and SNS) was found at a mean Frequency of 0.15 Hz (for an average healthy person). However, for each individual, this transition point varies.
Nerve-Express was able to come up with a calculation which is unique to any given person.
In addition, Nerve-Express also dealt with the problem of reducing all possible variations of multiple parameters (20-30) into a quantitative relationship between only two parameters: SNS and PSNS.
Nerve-Express is the first and only system to solve this problem of SNS-PSNS quantification. This technological breakthrough is achieved by the application of Dr. Riftine's proprietary algorithms.
The original and all subsequent releases of Nerve-Express include Health-Express.
From 1997 to 2000 a validation study of Nerve-Express was conducted by J. Thomas Bigger, Jr., M.D., Head of Research Holter Laboratory, at Columbia University College of Physicians and Surgeons.
In 1998 a "real-time" (up to 48 hours) Autonomic assessment was added to Nerve-Express.
In May of 2001 the European registration (CE mark) for Nerve-Express was granted and in August of 2001 Nerve-Express was launched on the European market.
In 2003 another test was added - the Valsalva maneuver combined with Deep Breathing.
2004 it's became compatible with ambulatory Holter-Monitor for 24 hour Autonomic
assessment with possibility to see on one page difference between "sleep" time and
2008 it's became compatible with PBI PC ECG device wich enable to see one lead ECG
on the screen and printout after words any part of ECG.
2010 Patent "Quantitative assessment of Autonomic function based on Heart Rate Variability" is granted.
2010 Wireless Bluetooth device Zephyr HxM added to the list of compatible devices.
2011 Corscience, GMBx ECG wireless Bluetooth device added to the list of devices.